Tangeretin Tangeretin is a polymethoxy flavonoid found in citrus fruits. This compound exhibits a wide variety of health-related benefits, including anti-inflammatory, anti-allergic, anti-diabetic, anti-osteoporotic, and anticancer activities. In an in…
Tandutinib Tandutinib is an inhibitor of several kinases, including FMS-like tyrosine kinase 3 (FLT3), PDGFR, and Kit. Tandutinib exhibits anticancer chemotherapeutic and anti-angiogenic activities and currently shows mixed results in…
Tamsulosin Hydrochloride Tamsulosin is an α1-adrenergic receptor antagonist that is clinically used to treat benign prostatic hyperplasia (BPH). Tamsulosin inhibits peristaltic activity, increases bladder blood flow, and decreases bladder overactivity.…
Tamoxifen Citrate Tamoxifen is a selective estrogen receptor modulator (SERM) that acts as an ER agonist in the endometrium and as an ER antagonist in breast tissue; it also inhibits…
Tamibarotene Tamibarotene is an agonist at retinoic acid receptors (RARs) and is selective primarily for RARα/β. Tamibarotene exhibits neuroprotective, cognition enhancing, immunomodulatory, and anticancer chemotherapeutic benefits. Tamibarotene upregulates tropomysin-related kinase…
TAK-733 TAK-733 is an inhibitor of MEK that exhibits anticancer chemotherapeutic activity. In tumor explant models, TAK-733 induces tumor regression. In colorectal cancer cells and melanoma cells, this compound suppresses…
TAK-632 TAK 632 is a benzothiazole pan-Raf inhibitor that displays anticancer chemotherapeutic activity. TAK 632 induces dimerization of Raf but prevents kinase activity. This compound inhibits cellular proliferation of melanoma…
TAE-226 TAE-226 is an inhibitor of focal adhesion kinase (FAK) that exhibits anti-angiogenic and anticancer activities. In vitro, this compound inhibits angiogenesis, decreases the viability of cancer cells, and suppresses…
Tacrolimus Tacrolimus is a calcineurin inhibitor that exhibits immunosuppressive, anti-fibrotic, anti-inflammatory, and anti-allergic activities. Clinically, tacrolimus is used to treat atopic dermatitis and conjunctivitis. In vivo, tacrolimus inhibits synthesis of…
T2 Triol T2 triol is a Fusarium trichothecene mycotoxin. In vitro, this compound displays significant cytotoxic activity, inducing breakdown of polyribosomes and inhibiting polypeptide chain elongation in eukaryotes. Additionally, T2…