GSK-461364
GSK-461364 GSK-461364 is an inhibitor of polo-like kinase 1 (PLK1) that is currently in clinical trials as a potential treatment for solid tumor cancers. GSK-461364 displays anticancer chemotherapeutic activity as…
2017
GSK-429286A
GSK-429286A GSK-429286A is an inhibitor of ROCK1/2 that also exhibits some inhibition of RSK and p70S6K. GSK-429286A displays antihypertensive activity, decreasing mean arterial pressure in spontaneously hypertensive rats. References PubMed…
GSK-343
GSK-343 GSK-343 is an inhibitor of enhancer of zeste homolog 2 (EZH2) histone methyltransferase (HMT). GSK-343 exhibits anticancer activity, inhibiting cell invasion and cell growth in epithelial ovarian cancer cells.…
GSK-2830371
GSK-2830371 GSK-2830371 is an inhibitor of wild-type p53-induced phosphatase 1 (Wip1) that exhibits anticancer chemotherapeutic activity. In animal models of lymphoma, GSK-2830371 inhibits cell growth and tumor growth. In neuroblastoma…
GSK-2636771
GSK-2636771 GSK-2636771 is an inhibitor of the p110β isoform of PI3K. GSK-2636771 displays anticancer chemotherapeutic activity in PTEN-deficient cancers such as glioblastomas, prostate cancers, and endometrial cancers. This compound is…
GSK-2606414
GSK-2606414 GSK-2606414 is an inhibitor of PERK, or eukaryotic initiation factor 2-α kinase 3 (EIK2AK3, also known as protein kinase R-like endoplasmic reticulum kinase). GSK-2606414 exhibits anticancer chemotherapeutic benefit, inhibiting…
GSK-2334470
GSK-2334470 GSK-2334470 is a selective inhibitor of PI3K that exhibits anticancer activity in in vitro models. GSK-2334470 inhibits T-loop phosphorylation of PI3K substrates SGK and S6K1, Akt and Akt substrates…
GSK-2126458
GSK-2126458 GSK-2126458 is an ATP-competitive PI3K and mTOR inhibitor somewhat specific for the p110α isoform of PI3K. This compound exhibits anticancer chemotherapeutic activity, inhibiting growth in cellular models. GSK-2126458 is…
GSK-1070916
GSK-1070916 GSK-1070916 is an inhibitor of aurora kinases B and C (AurB/C) that exhibits anticancer chemotherapeutic activity. GSK-1070916 prevents AurB from phosphorylating serine 10 of histone H3. In cellular and…
GS-9973
GS-9973 GS-9973 is an imidazopyrazine inhibitor of Syk that is currently in clinical trials as a potential treatment for chronic lymphocytic leukemia (CLL). GS-9973 exhibits anticancer chemotherapeutic activity. In vitro,…