Interleukin-6 Receptor Fragment
Interleukin-6 Receptor Fragment This peptide fragment of the soluble IL-6 receptor binds IL-6 weakly but does not display significant downstream signaling effects. This peptide may be used to measure presence…
2017
Indirubin
Indirubin Indirubin is a bisindole isomer of indigo found in Indigo naturalis. Indirubin exhibits anti-inflammatory, anti-angiogenic, and anticancer chemotherapeutic activities. In vivo, indirubin decreases levels of IgE and production of…
Indapamide
Indapamide Indapamide is a thiazide-like diuretic that exhibits antihypertensive and anti-fibrotic activities. Indapamide is clinically used to treat hypertension and heart failure. Indapamide blocks the slow component of delayed rectifier…
INCB018424
INCB018424 INCB018424 is an inhibitor of JAK1/2 that is clinically used to treat rheumatoid arthritis and myelofibrosis. INCB018424 exhibits anticancer, anti-inflammatory, and antiviral activities. In myeloma cells, INCB018424 inhibits cell…
INCB-28060
INCB-28060 INCB28060 is an inhibitor of c-MET that exhibits anticancer chemotherapeutic activity. In cellular models of cancer, INCB28060 inhibits cell migration and induces apoptosis, inhibiting proliferation. In animal models, this…
Inauhzin
Inauhzin Inauhzin is an inhibitor of SIRT1 that activates p53; it also inhibits inosine monophosphate dehydrogenase (IMPDH). Inauhzin exhibits anticancer chemotherapeutic activities, inducing apoptosis and suppressing cell growth in non-small…
Icilin
Icilin Icilin is an agonist at transient receptor potential melastatin 8 (TRPM8) channels; it may block transient receptor potential vanilloid 3 (TRPV3) channels. Icilin displays both hyperalgesic and analgesic activities…
Icariin
Icariin Icariin is a flavonol glycoside originally found in Epimedium that exhibits vasodilatory, antidepressant, neuroprotective, antioxidative, and anti-osteoporotic activities. Icariin inhibits phosphodiesterase 5 (PDE5), increasing cGMP and NO concentrations. Icariin…
Hypothemycin
Hypothemycin Hypothemycin is a polyketide found in Setophoma that exhibits anticancer, antifungal, and anti-parasitic activities. Hypothemycin is a resorcyclic acid lactone. This compound inhibits cell survival in melanoma and colon…
Hypocrellin A
Hypocrellin A Hypocrellin A exhibits antibacterial and immunomodulatory activities. In vitro, hypocrellin A inhibits MHC II antigen presentation but not MHC I antigen presentation. Additionally, this compound increases levels of…