LBH-589
LBH-589 LBH-589 is a hydroxamic acid inhibitor of class I (1, 2, 3, and 11) histone deacetylases (HDACs) that is clinically used to treat multiple myeloma and is currently in…
2017
LB-100
LB-100 LB-100 is an inhibitor of protein phosphatase 2A (PP2A) that exhibits pro-angiogenic and anticancer activities. LB-100 increases expression of VEGF and HIF-1α. This compound also decreases growth of pancreatic…
Lavendustin A
Lavendustin A Lavendustin A inhibits various tyrosine kinases and exhibits neuroprotective activity, increasing axonal outgrowth in neurons; this compound is used in research models to examine the effects of tyrosine…
Latrunculin B
Latrunculin B Latrunculin B is a thiazolidinone macrolide found in the Red Sea sponge. Latrunculin acts as an actin inhibitor, binding to G-actin and preventing its transition to F-actin and…
Latrunculin A
Latrunculin A Latrunculin A is a thiazolidine macrolide found in the Red Sea sponge. Latrunculin A binds actin, releasing RhoA effector mDia1 and inhibiting microtubule polymerization in vitro. Latrunculin A…
Lappaconitine
Lappaconitine Lappaconitine is an alkaloid originally found in species of Aconitum that exhibits analgesic, antinociceptive, anti-inflammatory, anti-arrhythmic, and antiepileptic/anticonvulsant activities. Lappaconitine increases pain threshold and downregulates expression of P2X3 receptors…
Lapatinib Ditosylate Monohydrate
Lapatinib Ditosylate Monohydrate Lapatinib is an inhibitor of EGFR/HER2 (ErbB2) that is currently in clinical trials as a co-administered treatment with other chemotherapeutics. Lapatinib exhibits anticancer chemotherapeutic benefit, inducing apoptosis…
Lansoprazole
Lansoprazole Lansoprazole is a proton pump (H+/K+ ATPase) inhibitor (PPI) that exhibits antacid and anti-inflammatory activities. Lansoprazole is clinically used to treat gastroesophageal reflux disease (GERD). Lansoprazole inhibits indomethacin-induced gastric…
Lamotrigine
Lamotrigine Lamotrigine exhibits antiepileptic/anticonvulsant, antidepressant, antinociceptive, and anxiolytic activities. Lamotrigine inhibits R-type Cav2.3 voltage-gated Ca2+ channels and voltage-gated Na+ channels, suppressing release of glutamate. In animals undergoing the forced swim…
Lamivudine
Lamivudine Lamivudine is an antiviral compound clinically used as a treatment for hepatitis B infection; it acts as a thymidine analog, inhibiting the reverse transcriptase enzyme. In two separate in…