Molsidomine Molsidomine is a NO donor that exhibits vasodilatory, cardioprotective, anti-atherosclerotic, and anticoagulant activities. Molsidomine inhibits PDGF-induced smooth muscle cell migration and proliferation and suppresses carotid artery neointima formation in…
Moguisteine Moguisteine is a non-narcotic anti-tussive compound that is used to prevent chronic cough. Moguisteine may derive its function through inhibition of rapidly-adapting irritant receptors or through activation of ATP-sensitive…
Moclobemide Moclobemide is a reversible inhibitor of MAO-A that exhibits antidepressant, anti-inflammatory, antinociceptive, and neuromodulatory activities. Moclobemide decreases immobility time in animals undergoing the forced swim test and suppresses LPS-induced…
MLN8237 MLN8237 inhibits aurora kinase A (AurA) preventing mitotic spindle formation and proper completion of mitosis. MLN8237 exhibits anticancer chemotherapeutic activity and is currently in clinical trials as a potential…
MLN2480 MLN2480 is an oral pan-Raf inhibitor designed to inhibit cell proliferation and survival. MLN2480 is currently in clinical trials and displays anticancer chemotherapeutic activity. References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18945538 Cas No.…
MLN-4924 MLN4924 acts as a Nedd8-activating enzyme inhibitor, blocking proteasomal cullin protein neddylation by Cullin-RING E3 ubiquitin ligases. As a result, these proteins accumulate, inducing cell cycle arrest, senescence, autophagy,…
MLN-2238 MLN-2238 is a proteasome inhibitor that modulates miR33b, a tumor suppressor microRNA. MLN-2238 exhibits anticancer activity, downregulating Pim-1 activity in multiple myeloma cells. References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18945487 Cas No. 1072833-77-2…
MK-2461 MK-2461 is an inhibitor of MET that also shows inhibition of FGFR and PDGFR. In animal models of glioblastoma and gastric cancer, MK-2461 exhibits anticancer chemotherapeutic activity, decreasing tumor…
MK-2206 MK-2206 is an allosteric inhibitor of Akt that prevents translocation of Akt to membranes. MK-2206 exhibits anticancer chemotherapeutic activity in a variety of in vitro cancer models; this compound…
MK-0524 MK-0524 is a specific prostaglandin D2 receptor (DP1) inhibitor that functions as an inverse agonist. MK-0524 decreases niacin-induced flushing during niacin treatment of dyslipidemia and is most often studied…