Lenalidomide Lenalidomide displays anti-inflammatory, anti-angiogenic, immunosuppressive, and anticancer chemotherapeutic benefits in the treatment of multiple myeloma and myelodysplastic syndromes associated with chromosome 5q deletions. Lenalidomide is a derivative of thalidomide…
Leflunomide Leflunomide inhibits dihydroorotate dehydrogenase, preventing UMP formation and pyrimidine synthesis. Metabolites of leflunomide may inhibit various kinases such as JNK and JAK. Leflunomide is clinically used to treat rheumatoid…
LDK378 LDK-378 is an anaplastic lymphoma kinase (ALK) inhibitor that displays anticancer chemotherapeutic activity. LDK-378 is used to treat ALK-positive non-small cell lung cancer (NSCLC), particularly in subjects experiencing resistance…
LCL-161 LCL-161 is a second mitochondria-derived activator of caspases (SMAC) mimetic that binds to cIAP1 and cIAP2 (members of the inhibitors of apoptosis family of proteins, often upregulated in many…
LBH-589 LBH-589 is a hydroxamic acid inhibitor of class I (1, 2, 3, and 11) histone deacetylases (HDACs) that is clinically used to treat multiple myeloma and is currently in…
LB-100 LB-100 is an inhibitor of protein phosphatase 2A (PP2A) that exhibits pro-angiogenic and anticancer activities. LB-100 increases expression of VEGF and HIF-1α. This compound also decreases growth of pancreatic…
Lavendustin A Lavendustin A inhibits various tyrosine kinases and exhibits neuroprotective activity, increasing axonal outgrowth in neurons; this compound is used in research models to examine the effects of tyrosine…
Latrunculin B Latrunculin B is a thiazolidinone macrolide found in the Red Sea sponge. Latrunculin acts as an actin inhibitor, binding to G-actin and preventing its transition to F-actin and…
Latrunculin A Latrunculin A is a thiazolidine macrolide found in the Red Sea sponge. Latrunculin A binds actin, releasing RhoA effector mDia1 and inhibiting microtubule polymerization in vitro. Latrunculin A…
Lappaconitine Lappaconitine is an alkaloid originally found in species of Aconitum that exhibits analgesic, antinociceptive, anti-inflammatory, anti-arrhythmic, and antiepileptic/anticonvulsant activities. Lappaconitine increases pain threshold and downregulates expression of P2X3 receptors…