Mefenamic Acid Mefenamic acid is a fenamate non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, neuroprotective, anticancer, and neuromodulatory activities. Mefenamic acid is a non-selective inhibitor of COX-1 and COX-2…
Medroxyprogesterone 17-Acetate Medroxyprogesterone 17-acetate (MPA) is a synthetic steroid that activates progesterone, androgen, and glucocorticoid receptors. MPA exhibits contraceptive and anticancer activities and is also used in hormone replacement therapy,…
Mechlorethamine Hydrochloride Mechlorethamine is a nitrogen mustard DNA alkylator that binds and alkylates the N7 nitrogen on guanine and adenine bases in DNA. Mechlorethamine was initially developed as a blistering…
Mecamylamine Hydrochloride Mecamylamine is a reversible, non-competitive, non-selective inhibitor of nicotinic acetylcholine receptors (nAChRs); it decreases channel open time and burst duration. This compound exhibits antihypertensive, antidepressant, and anxiolytic activities.…
Mebendazole Mebendazole is a benzimidazole anti-parasitic/anti-helminthic compound that also exhibits anticancer chemotherapeutic activity. Mebendazole inhibits microtubule polymerization in parasitic worms. In melanoma cells, mebendazole decreases levels of Bcl-2 and induces…
MDL 29951 MDL 29951 acts as an agonist at GPR17, inhibiting maturation of primary oligodendrocytes and potentially promoting myelin repair in models of multiple sclerosis. MDL 29951 also inhibits NMDA…
Mdivi-1 Mdivi-1 is a quinazolinone inhibitor of mitochondrial division that prevents mitochondrial fission and exhibits neuroprotective, cardioprotective, and anti-metastatic properties. In spinal cord injury models, Mdivi-1 decreases neuronal apoptosis and…
MC1568 MC1568 interferes with myogenic signaling by blocking HDAC enzymatic activity and MEF2-mediated transactivation in C2C12 cells. Exposure of rat intestinal epithelial cell line EIC-18 to MC1568 prevented stimulation of…
Matrix GLa Protein – pNa Matrix GLa protein inhibits vascular calcification in a vitamin K-dependent manner. Serum levels of this peptide may be used as a biomarker for renal failure,…
Matrine Matrine is an alkaloid found in Sophora that exhibits anticancer chemotherapeutic, antinociceptive, anti-inflammatory, neuroprotective, anti-fibrotic, and antiepileptic/anticonvulsant activities. Matrine increases levels of Bax and decreases levels of Bcl-2 and…