NMS-1286937
NMS-1286937 NMS-1286937 is an inhibitor of polo-like kinase 1 (PLK1) that is currently in clinical trials as a potential treatment for various cancers; it exhibits anticancer chemotherapeutic activity. In osteosarcoma…
June 2017
NLG919
NLG919 NLG919 is an inhibitor of indoleamine-2,3-dioxygenase (IDO). This compound displays anticancer chemotherapeutic activity, prolonging survival rates in animal models of glioblastoma. References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18949383 Cas No. 1402836-58-1 Purity ≥98%…
Nizatidine
Nizatidine Nizatidine is an inverse agonist at histamine H2 receptors that exhibits antacid and immunostimulatory activities. Nizatidine shortens gastric emptying time in clinical settings. Additionally, this compound stimulates maturation of…
Nivalenol
Nivalenol Nivalenol is a Fusarium type B trichothecene mycotoxin. Nivalenol is cytotoxic to leukocytes, inhibiting cell proliferation, increasing IL-8 secretion, and decreasing MCP-1 secretion in an NF-κB-dependent manner. In macrophages…
Nitroso(acetoxymethyl)methylamine
Nitroso(acetoxymethyl)methylamine This compound is a precursor of NNK found in tobacco smoke; it exhibits immunosuppressive, mutagenic, and carcinogenic activities. In alveolar and bronchial epithelial cells, this compound inhibits production of…
Nitrendipine
Nitrendipine Nitrendipine is an L-type calcium channel blocker which research has shown to have a potent inhibitory effect on human carboxylesterase, a member of the serine hydrolase family, in vitro.…
Nitisinone
Nitisinone Nitisinone is a nitrobenzene inhibitor of HPPD, an enzyme involved in tyrosine degradation. Nitisinone is clinically used to slow the effects of hereditary type 1 tyrosinemia and as a…
Nitidine Chloride
Nitidine Chloride Nitidine is a benzophenanthridine alkaloid that exhibits anticancer chemotherapeutic, anti-inflammatory, anti-parasitic, and antifungal properties. In cancer cells, nitidine decreases phosphorylation of Akt and downregulates expression of matrix metalloproteinases…
Nisoldipine
Nisoldipine Nisoldipine is an L-type Ca2+ channel blocker which with long-term treatment can prevent the development of hypertension and cardiac hypertrophy in young spontaneously hypertensive rats. It is a dihydropyridine…
Nimustine Hydrochloride
Nimustine Hydrochloride Nimustine is a nitrosourea compound that exhibits anticancer chemotherapeutic activity. Nimustine induces DNA cross-linking and double-stranded DNA breaks. This compound is clinically used to treat gliomas and may…