Ranatensin
Ranatensin Ranatensin is a peptide originally found in amphibian skin that exhibits gastrointestinal motility modulating activity. Ranatensin stimulates Cl- secretion in the jejunum in a GRP-related manner. Ranatensin also stimulates…
June 2017
Ramosetron
Ramosetron Ramosetron is an inhibitor of 5-HT3 receptors that is currently in clinical trials as a treatment for chemotherapeutic-induced or postoperative nausea and vomiting; it also treats inflammatory bowel syndrome…
Ramoplanin
Ramoplanin Ramoplanin is a peptide antibiotic that displays antibacterial activity against aerobic and anaerobic gram positive bacteria such as Clostridium difficile. Ramoplanin inhibits bacterial growth by binding lipid II and…
Ramipril
Ramipril Ramipril is an angiotensin-converting enzyme (ACE) inhibitor that exhibits anti-arrhythmic, antihypertensive, and cardioprotective activities. In animal models of myocardial infarction, ramipril decreases ventricular tachycardia and ventricular fibrillation. In other,…
Ramatroban
Ramatroban Ramatroban is a thromboxane A2 (TxA2) receptor inhibitor that exhibits anti-allergic and anti-inflammatory properties. Ramatroban also competitively inhibits chemoattractant receptor-homologous molecule on Th2 cells (CRTH2), a relatively new prostaglandin…
Raltitrexed
Raltitrexed Raltitrexed is a quinazoline analog of folate. Raltitrexed acts as an antifolate anticancer chemotherapeutic, inhibiting thymidylate synthase. Raltitrexed disrupts DNA synthesis and induces strand breaks. This compound is approved…
Raltegravir
Raltegravir Raltegravir is an antiviral compound that inhibits HIV integrase; it is clinically used to treat HIV infection. In pre-clinical models, raltegravir decreases infection rates by preventing insertion of HIV-1…
Raloxifene Hydrochloride
Raloxifene Hydrochloride Raloxifene is a selective estrogen receptor modulator (SERM) that exhibits agonist activity in bone and antagonist activity in uterine and breast tissues. Raloxifene is clinically used to prevent…
RAF265
RAF265 RAF265 is an orally bioavailable anticancer chemotherapeutic compound that inhibits primarily WT B-Raf, mutant (V600E) B-Raf, and VEGFR2, but is also active against c-Raf, PDGFR, CSF-1R, RET, c-Kit, Src,…
Radicicol
Radicicol Radicicol is an analog of benzoquinone ansamycin that inhibits HSP90, Src family kinases, and Raf. Radicicol exhibits neuroprotective, antibiotic, antifungal, anti-parasitic, and antimalarial activities. In Plasmodium, radicicol targets topoisomerase…