Roscovitine
Roscovitine Roscovitine is an inhibitor of CDKs (1, 2, 5, 7, 9, 12) and L-type Ca2+ channels; it exhibits anti-inflammatory and anticancer activities. Roscovitine resolves neutrophil-driven inflammation. In B-cell lymphoma…
June 2017
Ropinirole Hydrochloride
Ropinirole Hydrochloride Ropinirole is an indoline agonist at D2/3 receptors that is clinically used to treat restless leg syndrome and Parkinson’s disease. Ropinirole prevents dopaminergic neuron damage and MPTP-induced changes…
Romidepsin
Romidepsin Romidepsin is a depsipeptide prodrug that inhibits histone deacetylases (HDACs). Romidepsin is currently in clinical trials as a potential treatment for T-cell lymphomas; it displays anticancer chemotherapeutic and antiviral…
Rolipram
Rolipram Rolipram is known to be an antidepressant and anxiolytic-like agent that has been found to stimulate angiogenesis and attentuate neuronal apoptosis in ischemic rats. References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18964309 Cas No.…
Rofecoxib
Rofecoxib Rofecoxib is a non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits COX-2; it exhibits anti-inflammatory, analgesic, antiepileptic/anticonvulsant, and chemopreventive activities but is no longer clinically administered. Rofecoxib inhibits the formation…
Rocuronium Bromide
Rocuronium Bromide Rocuronium is an aminosteroid that exhibits anesthetic activity, inducing relaxation of skeletal muscle. Rocuronium is a non-depolarizing neuromuscular junction (NMJ) blocker that inhibits post-synaptic nicotinic acetylcholine receptors (nAChRs);…
Ro 61-8048
Ro 61-8048 Ro 61-8048 inhibits kynurenine 3-hydroxylase, displaying anti-inflammatory and neuromodulatory activities. Ro 61-8048 is used to study kynurenine signaling in embryonic brain development. In models of trypanosomiasis, this compound…
Ro 20-1724
Ro 20-1724 Ro 20-1724 is a phosphodiesterase inhibitor that has been shown to enhance cognition in streptozocin treated rats. In addition to learning and memory improvements, Ro 20-1724 was also…
RN-486
RN-486 RN-486 is an inhibitor of Bruton’s tyrosine kinase (Btk) that is currently in development as a potential treatment for rheumatoid arthritis; it exhibits anti-inflammatory, nephroprotective, and immunosuppressive activities. RN-486…
RKI-1447
RKI-1447 RKI-1447 is an inhibitor of ROCK1/2 that exhibits anticancer chemotherapeutic activity. RKI-1447 also displays anti-metastatic potential, suppressing phosphorylation of MLC-2, MYPT-1, inhibiting formation of actin stress fibers, and preventing…