Sitagliptin Phosphate Monohydrate Sitagliptin is an anti-diabetic/anti-hyperglycemic compound that inhibits dipeptidyl peptidase 4 (DPP4); sitagliptin also exhibits antioxidative and cardioprotective benefit. Sitagliptin decreases release of lactate dehydrogenase, malondialdehyde, and creatine…
Sirtinol Sirtinol is a sirtuin inhibitor and iron chelator that exhibits antiviral, anti-inflammatory, anticancer, and anti-angiogenic activities. In vivo, sirtinol induces apoptosis-like changes in platelets, decreasing platelet count. In vitro,…
Siramesine Siramesine is an indole derivative that acts as an agonist at σ2 receptors, exhibiting anticancer, antidepressant, and anxiolytic activities. Siramesine decreases the mitochondrial membrane potential, increases cytochrome c release,…
Sinomenine Hydrochloride Sinomenine is an alkaloid found in Sinomenium that exhibits analgesic, neuroprotective, anti-inflammatory, immunomodulatory, anti-allergic, and anticancer chemotherapeutic activities. In vivo, sinomenine improves mechanical withdrawal threshold and cold pain…
Sinigrin Monohydrate, synthetic Sinigrin is an isothiocyanate precursor often found in vegetables belonging to the Brassicaceae family, such as Brussels sprouts, broccoli seeds, and mustard seeds. In vivo, sinigrin is…
Sincalide Sincalide is an octapeptide fragment of cholestocystokinin (CCK) that activates the CCK receptor on immune cell surfaces. Sincalide is more potent when sulfated. Sincalide exhibits neuroprotective, immunosuppressive, and anorexigenic…
Simvastatin Simvastatin is an inhibitor of HMG-CoA reductase that exhibits anti-hyperlipidemic, anticonvulsant/antiepileptic, anti-osteoporotic, neuroprotective, cognition enhancing, antithrombotic, and anticancer chemotherapeutic activities. Clinically, simvastatin decreases levels of LDL and total cholesterol…
Silymarin Silymarin is a flavonolignan mixture found in Silybum (milk thistle) seeds; it exhibits antiviral, anti-inflammatory, anti-fibrotic, hepatoprotective, neuroprotective, immunosuppressive, antioxidative, and anticancer activities. Silymarin inhibits influenza virus proliferation by…
Silybin Silybin is a phytoestrogen and flavonoid originally found in the seeds of the milk thistle plant (Silybum). Silybin exhibits anti-diabetic, anti-inflammatory, anti-angiogenic, anticancer chemotherapeutic, and chemopreventive activities. In cellular…
Silodosin Silodosin is a selective α1A-adrenergic receptor antagonist clinically used to treat benign prostatic hyperplasia/low urinary tract syndrome (BPH/LUTS). Silodosin improves bladder function and blood flow in ischemic conditions in…