(R)-FSL-1
(R)-FSL-1 (R)-FSL-1 is an agonist at toll-like receptors (TLR 2/6) that exhibits immunostimulatory, pro-inflammatory, and anticancer activities. FSL-1 increases IgE and IgA responses to foods during systemic antigenic challenge. In…
June 2017
(R)-CR8
(R)-CR8 (R)-CR8 is an analog of roscovitine that inhibits cyclin-dependent kinases (CDKs) 1/2/3/5/7/9; it displays anticancer and neuroprotective activities. (R)-CR8 induces apoptosis and downregulates expression of Mcl-1 in neuroblastoma cells.…
(E)-4-Hydroxytamoxifen
(E)-4-Hydroxytamoxifen (E)-4-Hydroxytamoxifen is the less active isomer of 4-hydroxytamoxifen. 4-Hydroxytamoxifen is the active metabolite of tamoxifen, a selective estrogen receptor modulator (SERM) that acts as an agonist or antagonist in…
(E,Z)-4-Hydroxytamoxifen
(E,Z)-4-Hydroxytamoxifen (E,Z)-4-Hydroxytamoxifen is a mixture of cis- and trans-isomers of 4-hydroxytamoxifen. 4-Hydroxytamoxifen is the active metabolite of tamoxifen, a selective estrogen receptor modulator (SERM) that acts as an agonist or…
(−)-Huperzine A
(−)-Huperzine A Huperzine A (HupA) is a sesquiterpene alkaloid derived from the fir-like moss Huperzia serrata; it exhibits anticonvulsant/antiepileptic, neuromodulatory, cognition enhancing, neuroprotective, and antinociceptive activities. HupA acts as a…
(−)-Gallocatechin
(−)-Gallocatechin (-)-Gallocatechin is a polyphenol originally derived from a variety of sources, including green tea, coffee, safflower, and almonds; it is the epimer of (-)-epigallocatechin. (-)-Gallocatechin, like other catechins, exhibits…
(−)-Epinephrine
(−)-Epinephrine (-)-Epinephrine is the active isomer of epinephrine, an endogenous hormone neurotransmitter. Epinephrine exhibits bronchodilatory, vasoconstrictive and cardiostimulantory/positive inotropic activities. Epinephrine acts as a non-selective agonist at both α- and…
(−)-Epigallocatechin
(−)-Epigallocatechin (-)-Epigallocatechin (EGC) is a flavanol/catechin originally found in Camilla and other plant sources; it exhibits antioxidative, neuromodulatory, antithrombotic/anticoagulant, anticancer, anti-metastatic, and anti-osteoporotic activities. EGC displays agonist activity at cannabinoid…
(−)-Epicatechin gallate
(−)-Epicatechin gallate (-)-Epicatechin gallate (ECG) is a flavanol/catechin originally found in Camilla and other plan sources; it exhibits antioxidative, neuromodulatory, anticancer, and anti-inflammatory activities. ECG displays agonist activity at cannabinoid…
(−)-Epicatechin
(−)-Epicatechin (-)-Epicatechin (EC) is a flavanol and catechin originally found in Camilla and other plant sources; it exhibits antioxidative, neuroprotective, anti-atherosclerotic, and cardioprotective activities. In animal models of myocardial ischemia/reperfusion,…