Diosmin Diosmin is a flavone found in Teucrium that exhibits neuroprotective, cardioprotective, antioxidative, anti-hyperlipidemic, anticancer, chemopreventive, and anti-inflammatory activities. Diosmin alleviates neurological deficits, decreases infarct volume, and upregulates expression of…
Diosmetin Diosmetin is an O-methylated flavone found in vetch and various citrus fruits; it exhibits antioxidative, anti-inflammatory, anticancer, and anti-osteoporotic activities. In animal models of AAPH-induced oxidative stress, diosmetin decreases…
Diosgenin Diosgenin is a steroidal saponin found in Dioscorea that exhibits anticancer, anti-inflammatory, neuroprotective, cognition enhancing, and anti-hyperlipidemic activities. In breast cancer cells, diosgenin inhibits cell migration, actin polymerization, Vav2…
Dinaciclib Dinaciclib inhibits CDK1/2/5/9, displaying anticancer chemotherapeutic activity. Dinaciclib is currently in clinical trials as a potential treatment for various cancers. In cellular models of acute leukemias, dinaciclib inhibits cell…
Diminazene Aceturate Diminazene is a diamidine compound that activates angiotensin-converting enzyme 2 (ACE2), opposing the effects of angiotensin II (AT II) and the AT1 receptor. Diminazene acts as an antibacterial…
Dimethyl Fumarate Dimethyl fumarate is a fumaric acid methyl ester that is clinically used to treat psoriasis and under investigation as a potential treatment for multiple sclerosis (MS). Dimethyl fumarate…
Dimethoxycurcumin Like its parent compound, curcumin, this curcuminoid exhibits anticancer, antioxidative, anti-inflammatory, and antibacterial activities. In breast cancer cells, dimethoxycurcumin alters mitochondrial membrane potential, decreases ATP synthase activity, and induces…
Dimebon Dihydrochloride Dimebon is an activator of AMPK, a potentiator of AMPA, and an inhibitor of L-type voltage-gated Ca2+ channels, NMDA receptors, H1/2 histamine receptors, α-adrenergic receptors, and 5-HT2C/5A/6 receptors.…
Diltiazem Hydrochloride Diltiazem is a benzothiazepine-type compound that acts as an inhibitor of L-type Ca2+ channels. Diltiazem exhibits anti-arrhythmic, anti-anginal, anti-inflammatory, and cardioprotective activities. In animal models, diltiazem inhibits expression…
Dihydrotanshinone Dihydrotanshinone is found in Salvia that exhibits neuromodulatory, anticancer, anti-inflammatory, anti-allergic, anti-diabetic, antithrombotic, vasodilatory, antihypertensive, and anti-angiogenic activities. Dihydrotanshinone binds to the P-site of acetylcholinesterase (AChE), inhibiting its activity…