EPZ6438
EPZ6438 EPZ-6438 is an inhibitor of EZH2, a histone methyltransferase (HMT) responsible for methylation of lysine and arginine residues and controls gene transcription fidelity in cells. EPZ-6438 displays anticancer chemotherapeutic…
June 2017
EPZ005687
EPZ005687 EPZ-005687 is a highly selective inhibitor of mutant EZH2, a histone methyltransferase (HMT) that exhibits point mutations at key residues Tyr641 and Ala677 in non-Hodgkin’s lymphoma and other cancers.…
EPZ-5676
EPZ-5676 EPZ-5676 is an inhibitor of DOT1L histone methyltransferase (HMT) that exhibits anticancer chemotherapeutic activity. In acute myelogenous leukemia (AML) cells with MLL gene translocations, EPZ-5676 displays cytotoxicity; in similar…
Eptifibatide
Eptifibatide Eptifibatide is an inhibitor of glycoprotein GP IIb/IIIa that exhibits antiplatelet/antithrombotic activity. Eptifibatide inhibits fibrinogen-mediated platelet aggregation and is clinically used to treat acute coronary syndrome. References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1892020/…
Eprinomectin
Eprinomectin Eprinomectin is a semi-synthetic avermectin that is clinically used to treat livestock and domestic animals; it exhibits anti-helminthic and anti-parasitic activities. Eprinomectin increases GABA release, causing neuromuscular paralysis in…
Epoxiconazole
Epoxiconazole Epoxiconazole is a triazole pesticide/fungicide with broad antifungal activity. Like many azole fungicides, epoxiconazole likely inhibits 14-α demethylase, inhibiting ergosterol production and fungal cell wall synthesis. Additionally, epoxiconazole may…
Epothilone D
Epothilone D Epothilone is an anticancer chemotherapeutic that acts as an anti-mitotic compound; it binds the taxane pocket of β-tubulin, using side chains to induce formation of a short helix…
Epothilone B
Epothilone B Epothilone is an anticancer chemotherapeutic and neuroprotective compound that acts as an antimitotic compound; it binds the taxane pocket of β-tubulin, using side chains to induce formation of…
Epothilone A
Epothilone A Epothilone is an anticancer chemotherapeutic that acts as an anti-mitotic compound; it binds the taxane pocket of β-tubulin, using side chains to induce formation of a short helix…
Eplerenone
Eplerenone Eplerenone displays antihypertensive, anti-inflammatory, and anti-angiogenic activities; it inhibits the mineralocorticoid receptor. Eplerenone inhibits aldosterone-induced expression of COX (therefore decreasing PGE2 levels), preventing the induction of COX and resulting…