Glucagon-like Peptide I (7-37) Glucagon-like peptide 1 (GLP-1) is an endogenous peptide hormone that binds GLP-1 receptors, increasing cAMP and insulin secretion. GLP-1 primarily exhibits anorexigenic, anti-diabetic, and gastrointestinal modulatory…
Glucagon (19-29), human Glucagon (19-29) is also known as miniglucagon, an endogenous short peptide co-released with glucagon. Miniglucagon inhibits insulin secretion from pancreatic β-cells in a Ca2+-dependent manner. References PubMed…
GLPG-0634 GLPG-0634 is a triazolopyridine that inhibits JAK1; it exhibits anti-inflammatory and immunomodulatory activities. GLPG-0634 prevents release of inflammatory cytokines and is currently under investigation as a potential treatment for…
Glipizide Glipizide is a second generation sulfonylurea that exhibits anti-diabetic activity. Glipizide inhibits ATP-dependent K+ channels in β cells, forcing cells to remain depolarized, increasing Ca2+ influx and insulin secretion.…
Gliotoxin Gliotoxin was initially produced by the marine fungus Aspergillus and exhibits anticancer, immunosuppressive, and anti-fibrotic activities. In cervical cancer and chondrosarcoma cells, gliotoxin increases activation of caspases 3, 8,…
Glimepiride Glimepiride is a second generation sulfonylurea that exhibits anti-diabetic activity. Glimepiride inhibits ATP-dependent K+ channels in β cells, forcing cells to remain depolarized, increasing Ca2+ influx and insulin secretion.…
Gliclazide Gliclazide is a sulfonylurea compound that inhibits sulfonylurea 1 (SUR1) receptors, exhibiting anti-diabetic and antioxidative activities. Inhibition of these receptors closes K+ ion channels, inducing cell membrane depolarization, altering…
Glabridin Glabridin is a phytoestrogen and isoflavonoid originally found in the root of the licorice plant, Glycyrrhiza. Glabridin displays antioxidative, anti-obesity, anti-angiogenic, neuromodulatory, cognition enhancing, and sedative/hypnotic characteristics. In osteoblasts,…
GLa Peptide GLA peptide is an antimicrobial peptide (AMP) found in the skin of amphibians. References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18927357 Cas No. 102068-15-5 Purity ≥98% Formula C88H162N26O22S Formula Wt. 1968.5 Chemical Name…
Ginsenoside Rh2 Ginsenoside Rh2 is a triterpene saponin found in Panax and exhibits anticancer chemotherapeutic, anti-metastatic, neuroprotective, cognition enhancing, anti-inflammatory, anti-osteoporotic, antioxidative, and anti-diabetic activities. Ginsenoside Rh2 inhibits aldose reductase…