Phalloidin
Phalloidin is a phallotoxin found in Amanita phalloides that exhibits cytotoxic activity. Phalloidin binds F-actin and inhibits depolymerization; it locks adjacent subunits together, preventing actin ATP hydrolysis. Fluorescent-tagged conjugates of phalloidin are used to measure distribution of F-actin in vitro.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18953331
| Cas No. |
17466-45-4 |
|---|---|
| Purity |
≥95% |
| Formula |
C35H48N8O11S |
| Formula Wt. |
788.87 |
| Chemical Name |
Cyclic(L-alanyl-D-threonyl-L-cysteinyl-cis-4-hydroxy-L-prolyl-L-alanyl-2-mercapto-L-tryptophyl-4,5-dihydroxy-L-leucyl), cyclic (3,6)-sulfide |
| Synonym |
Phalloidine |
| Melting Point |
280-282°C |
| Solubility |
Soluble in methanol, ethanol, butanol, pyridine or hot water. |
| Appearance |
White powder |
Cooper JA. Effects of cytochalasin and phalloidin on actin. J Cell Biol. 1987 Oct;105(4):1473-8. PMID: 3312229.
Barden JA, Miki M, Hambly BD, et al. Localization of the phalloidin and nucleotide-binding sites on actin. Eur J Biochem. 1987 Feb 2;162(3):583-8. PMID: 3830158.
