Pentagastrin
Pentagastrin is a synthetic polypeptide that stimulates gastric acid secretion on the gastrointestinal tract in a cholinergic signaling-dependent manner. Pentagastrin inhibits motilin-induced contractions in the stomach in animal models. Pentagastrin also enhances gastric defense by increasing mucus gel thickness, mucosal blood flow, and pHi.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18952825
| Cas No. |
5534-95-2 |
|---|---|
| Purity |
≥95% |
| Formula |
C37H50N7O9S |
| Formula Wt. |
768.79 |
| Chemical Name |
(3S)-4-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-[[(2S)-2-[[(2S)-3-(1H-indol-3-yl)-2-[3-(2-methylpropoxycarbonylamino)propanoylamino]propanoyl]amino]-4-methylsulfanylbutanoyl]amino]-4-oxobutanoic acid |
| IUPAC Name |
4-[[(2R)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-[[(2R)-2-[[(2S)-3-(1H-indol-3-yl)-2-[3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoylamino]propanoyl]amino]-4-methylsulfanylbutanoyl]amino]-4-oxobutanoic acid |
| Synonym |
Gastrodiagnost, Pentagastrinum, Peptavlon, Petogasrin |
| Melting Point |
229°C |
| Appearance |
White to off-white powder |
Beckert S, Wolf SC, Farrahi F, et al. TGF-beta3 inhibits pentagastrin-stimulated gastric acid secretion in rats. Med Sci Monit. 2005 Mar;11(3):BR80-3. PMID: 15735558.
Yamamoto O, Matsunaga Y, Shiba Y, et al. Inhibition of motilin-induced phase III contractions by pentagastrin in Heidenhain pouch dogs. J Pharmacol Exp Ther. 1994 Dec;271(3):1471-6. PMID: 7996460.
Nishizaki Y, Guth PH, Kim G, et al. Pentagastrin enhances gastric mucosal defenses in vivo: luminal acid-dependent and independent effects. Am J Physiol. 1994 Jul;267(1 Pt 1):G94-104. PMID: 8048536.
Zwick R, Bowes KL, Daniel EE, et al. Mechanism of action of pentagastrin on the lower esophageal sphincter. J Clin Invest. 1976 Jun;57(6):1644-51. PMID: 932198.
