Levonorgestrel
Levonorgestrel is a synthetic progestogen that exhibits contraceptive activity, inhibiting secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Levonorgestrel is clinically used in hormonal contraceptives and hormone replacement therapy. In vitro, levonorgestrel increases expression of 17-β hydroxysteroid dehydrogenase.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18940117
| Cas No. |
797-63-7 |
|---|---|
| Purity |
≥98% |
| Formula |
C21H28O2 |
| Formula Wt. |
312.45 |
| Chemical Name |
17-Ethynyl-18-methyl-19-nortestosterone |
| IUPAC Name |
(8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one |
| Synonym |
D(−) Norgestrel; Microlut; Microval; Norgeston; Norlevo; Norplant |
| Melting Point |
235-237°C |
| Solubility |
Insoluble in water. Slightly soluble in alcohol. |
| Appearance |
White Crystal Powder |
Gemzell-Danielsson K, Berger C, P G L L. Emergency contraception — mechanisms of action. Contraception. 2013 Mar;87(3):300-8. PMID: 23114735.
Yuan P, Chen B, Huang Y, et al. Long-term regression of experimental endometriosis in a rat model treated with local application of levonorgestrel-loaded biodegradable microspheres. Hum Reprod. 2012 Jul;27(7):2089-95. PMID: 22563024.
Sarkar NN. The emergency contraceptive drug, levonorgestrel: a review of post-coital oral and peri-coital vaginal administration for prevention of pregnancy. J Obstet Gynaecol. 2011 Nov;31(8):703-7. PMID: 22085058.
