Mouse CD200/OX-2 Protein 3839

Additional Information:
accession O54901|express systemHEK293|product tagC-His|purity> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC|backgroundCD200 and its receptors are highly expressed in the lung, on epithelial cells and leukocytes, and emerging evidence links dysregulation of the CD200 pathway with asthma. Moreover, pharmacological modulation of CD200 receptors was shown to improve clinical and inflammatory outcomes of preclinical asthma models.|molecular weightThe protein has a predicted MW of 23.6 kDa. Due to glycosylation, the protein migrates to 45-60 kDa based on Tris-Bis PAGE result.|available size100 g, 500 g|endotoxinLess than 1EU per g by the LAL method.|Mouse CD200/OX-2 Protein 3839proteinSize and concentration100, 500g and lyophilizedFormLyophilizedStorage InstructionsValid for 12 months from date of receipt when stored at -80C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.Storage bufferShipped at ambient temperature.Purity> 95% as determined by Tris-Bis PAGEtarget relevanceCD200 and its receptors are highly expressed in the lung, on epithelial cells and leukocytes, and emerging evidence links dysregulation of the CD200 pathway with asthma. Moreover, pharmacological modulation of CD200 receptors was shown to improve clinical and inflammatory outcomes of preclinical asthma models.Protein namesOX-2 membrane glycoprotein (MRC OX-2 antigen) (CD antigen CD200)Gene namesCD200,CD200 Mox2Mass10090DaFunctionCostimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues (By similarity).Subellular locationCell membrane; Single-pass type I membrane protein.StructureCD200 and CD200R1 interact via their respective N-terminal Ig-like domains.Target Relevance information above includes information from UniProt accession: O54901The UniProt Consortium|