Acitretin
Acitretin is an orally bioavailable retinoid that displays anti-inflammatory activity and is used clinically to treat psoriasis. Acitretin is a metabolite of etretinate that displays more optimized pharmacokinetic parameters. This compound activates all retinoic acid receptor subtypes (RARα/β/γ) without binding the receptor itself and also increases cAMP-PKA binding in erythrocytes.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18835749
| Cas No. |
55079-83-9 |
|---|---|
| Purity |
≥98%, multiple isomers |
| Formula |
C21H26O3 |
| Formula Wt. |
326.43 |
| Chemical Name |
9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid |
| IUPAC Name |
(2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid |
| Synonym |
Neotigason; Soriatane |
| Appearance |
Yellow to green-yellow crystalline powder |
Niu X, Cao W, Ma H, et al. Acitretin exerted a greater influence on T-helper (Th)1 and Th17 than on Th2 cells in treatment of psoriasis vulgaris. J Dermatol. 2012 Nov;39(11):916-21. PMID: 22913391.
Saurat JH. Retinoids and psoriasis: novel issues in retinoid pharmacology and implications for psoriasis treatment. J Am Acad Dermatol. 1999 Sep;41(3 Pt 2):S2-6. PMID: 10459139.
Raynaud F, Gerbaud P, Bouloc A, et al. Rapid effect of treatment of psoriatic erythrocytes with the synthetic retinoid acitretin to increase 8-azido cyclic AMP binding to the RI regulatory subunit. J Invest Dermatol. 1993 Jan;100(1):77-81. PMID: 8380830.
