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Ac-SDKP

Ac-SKDP is a pro-angiogenic peptide degradation product of thymosin B4 that regulates hematopoiesis by inhibiting proliferation of hematopoietic pluripotent stem cells (spleen colony-forming units, or CFUs). This peptide exhibits cardioprotective, anti-inflammatory, and anti-fibrotic activities. In animal models of chronic myocardial infarction, Ac-SDKP improves left ventricular function, increases angiogenesis, and decreases infarct size. In hypertensive rats, Ac-SDKP prevents angiotensin II-induced increases in collagen synthesis and cross-linking as well as expression of LOX and TGF-β and activation of NF-κB and lymphocytic immune cells. In other animal models, this peptide prevents fibrosis, decreasing deposition of fibronectin and collagen and decreasing the number of myofibroblasts and macrophages. Ac-SDKP also exhibits nephroprotective activity, inhibiting progression of lupus nephritis in animal models; Ac-SDKP decreases proteinuria, infiltration of inflammatory T cells and macrophages, production of TNF-α, activation of NF-κB, and phosphorylation of Smad2/3, resulting in improvements in renal function.

References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/18835430

Cas No.

120081-14-3

Purity

≥95%

Formula

C20H33N5O9

Formula Wt.

487.51

IUPAC Name

(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carboxylic acid

Synonym

Goralatide

Appearance

White to off white powder

Song M, Jang H, Lee J, et al. Regeneration of chronic myocardial infarction by injectable hydrogels containing stem cell homing factor SDF-1 and angiogenic peptide Ac-SDKP. Biomaterials. 2014 Mar;35(8):2436-45. PMID: 24378015.

González GE, Rhaleb NE, Nakagawa P, et al. N-acetyl-seryl-aspartyl-lysyl-proline reduces cardiac collagen cross-linking and inflammation in angiotensin II-induced hypertensive rats. Clin Sci (Lond). 2014 Jan 1;126(1):85-94. PMID: 23834332.

Zuo Y, Chun B, Potthoff SA, et al. Thymosin β4 and its degradation product, Ac-SDKP, are novel reparative factors in renal fibrosis. Kidney Int. 2013 Dec;84(6):1166-75. PMID: 23739235.

Tan H, Zhao J, Wang S, et al. Ac-SDKP ameliorates the progression of lupus nephritis in MRL/lpr mice. Int Immunopharmacol. 2012 Dec;14(4):401-9. PMID: 22922317.

Lenfant M, Wdzieczak-Bakala J, Guittet E, et al. Inhibitor of hematopoietic pluripotent stem cell proliferation: purification and determination of its structure. Proc Natl Acad Sci U S A. 1989 Feb;86(3):779-82. PMID: 2915977.

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