AG-1024
AG-1024 is a tyrphostin that inhibits IGF-1R, exhibiting anticancer chemotherapeutic activity. In hepatocellular carcinoma cells and breast cancer cells, AG-1024 increases levels of cytochrome C, decreases activation of ERK, and inhibits invasion and proliferation.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18837079
| Cas No. |
65678-07-1 |
|---|---|
| Purity |
≥98% |
| Formula |
C14H13BrN2O |
| Formula Wt. |
305.17 |
| IUPAC Name |
2-[(3-bromo-5-tert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile |
| Synonym |
AG1024 (tyrphostin) |
| Appearance |
Light tan to light orange solid |
Yao WF, Liu JW, Sheng GL, et al. Blockade of IGF-IR exerts anticancer effects in hepatocellular carcinoma. Mol Med Rep. 2011 Jul-Aug;4(4):719-22. PMID: 21567089.
Chakraborty AK, Welsh A, Digiovanna MP. Co-targeting the insulin-like growth factor I receptor enhances growth-inhibitory and pro-apoptotic effects of anti-estrogens in human breast cancer cell lines. Breast Cancer Res Treat. 2010 Apr;120(2):327-35. PMID: 19337828.
