5-Fluorouracil
5-Fluorouracil (5-FU) is an antimetabolite pyrimidine analog that exhibits anticancer chemotherapeutic activity; it inhibits thymidylate synthase, preventing thymidine synthesis. 5-FU is clinically used to treat various cancers and is often co-administered with other chemotherapeutics to decrease its peripheral cytotoxicity.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18834431
| Cas No. |
51-21-8 |
|---|---|
| Purity |
≥98% |
| Formula |
C4H3FN2O2 |
| Formula Wt. |
130.08 |
| Chemical Name |
5-Fluoro-2,4(1H,3H)-pyrimidinedione |
| IUPAC Name |
5-fluoro-1H-pyrimidine-2,4-dione |
| Synonym |
Fluorouracil; 5-FU; 2,4-dioxo-5-fluoropyrimidine |
| Melting Point |
282-283°C(dec.) |
| Solubility |
Slightly soluble in water (12mg/mL). |
| Appearance |
White Crystal Powder |
Papanastasopoulos P, Stebbing J. Molecular basis of 5-fluorouracil-related toxicity: lessons from clinical practice. Anticancer Res. 2014 Apr;34(4):1531-5. PMID: 24692679.
Longley DB, Harkin DP, Johnston PG. 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer. 2003 May;3(5):330-8. PMID: 12724731.
