3-Methyladenine
3-Methyl adenine is an autophagy inhibitor that also inhibits DNA polymerase activity and DNA synthesis if incorporated into DNA. Additionally, 3-methyl adenine exhibits antioxidative benefit, decreasing levels of lactate dehydrogenase and ROS/RNS in hydroquinone- and rapamycin-treated cells.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18832967
| Cas No. |
5142-23-4 |
|---|---|
| Purity |
≥98% |
| Formula |
C6H7N5 |
| Formula Wt. |
149.15 |
| IUPAC Name |
3-methylpurin-6-amine |
| Synonym |
3-MA, NSC 66389, NSC66389 |
| Appearance |
White to off white powder |
product targets : CRTH2 (GPR44) inhibitors
Ramírez C, Pham K, Franco MF, et al. Hydroquinone induces oxidative and mitochondrial damage to human retinal Müller cells (MIO-M1). Neurotoxicology. 2013 Dec;39:102-8. PMID: 23994029.
Kumar S, Guru SK, Pathania AS, et al. Autophagy triggered by magnolol derivative negatively regulates angiogenesis. Cell Death Dis. 2013 Oct 31;4:e889. PMID: 24176847.
Johnson RE, Yu SL, Prakash S, et al. A role for yeast and human translesion synthesis DNA polymerases in promoting replication through 3-methyl adenine. Mol Cell Biol. 2007 Oct;27(20):7198-205. PMID: 17698580.
