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3-Formylrifamycin

3-Formyl rifamycin is a rifamycin derivative antibiotic that induces pore formation in the mitochondrial membrane. Like other ansamycins, this compound is an ansamycin that inhibits DNA-dependent RNA polymerase. 3-Formyl rifamycin displays antibacterial efficacy against Mycobacterium.

References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/18832958

Cas No.

13292-22-3

Purity

≥98%

Formula

C38H47NO13

Formula Wt.

725.78

Chemical Name

2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-8-carboxaldehyde, 1,2-dihydro-5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-, 21-acetate

Synonym

Rifamycin SV-3 formyl; 3-Formylrifampicin SV; Rifaldehyde; Rifamycin AF

Melting Point

182-184°C

Appearance

A dark red crystalline powder


product targets : GPR55 inhibitors

Nedyalkova Z, Haladjova S, et al. QSAR Modeling of Antimycobacterial Activity and Activity Against Other Bacteria of 3-Formyl Rifamycin SV Derivatives. Mol inform. 2001 Nov;20(4): 298–318.

Sethi VS, Okano P. Interaction of rifamycins with mammalian nucleic acid polymerizing enzymes. Biochim Biophys Acta. 1976 Dec 1;454(2):230-47. PMID: 63293.

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