2-Hydroxyflutamide
2-Hydroxyflutamide is a non-steroidal anti-androgen that inhibits the androgen receptor. 2-Hydroxyflutamide exhibits anti-resorptive and anticancer activity. In osteoblasts, 2-hydroxyflutamide inhibits production of IL-6 and activation of NF-κB. In prostate cancer cells, this compound enhances the efficacy of other co-administered chemotherapeutics such as 5-fluorouracil.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18832145
| Cas No. |
52806-53-8 |
|---|---|
| Purity |
≥98% |
| Formula |
C11H11F3N2O4 |
| Formula Wt. |
292.21 |
| Chemical Name |
2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide |
| IUPAC Name |
2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide |
| Synonym |
Hydroxyniphtholide |
| Melting Point |
125-130°C |
| Appearance |
Yellow powder |
product targets : NKCC inhibitors
Kawabata R, Oie S, Oka T, et al. Hydroxyflutamide enhances cellular sensitivity to 5-fluorouracil by suppressing thymidylate synthase expression in bicalutamide-resistant human prostate cancer cells. Int J Oncol. 2011 Mar;38(3):665-76. PMID: 21243325.
Hofbauer LC, Ten RM, Khosla S. The anti-androgen hydroxyflutamide and androgens inhibit interleukin-6 production by an androgen-responsive human osteoblastic cell line. J Bone Miner Res. 1999 Aug;14(8):1330-7. PMID: 10457265.
Furr BJ, Valcaccia B, Curry B, et al. ICI 176,334: a novel non-steroidal, peripherally selective antiandrogen. J Endocrinol. 1987 Jun;113(3):R7-9. PMID: 3625091.
