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2,3,5,6-Tetramethylpyrazine

Tetramethylpyrazine is a dihydropyrazine found in Ligusticum walliichi that exhibits neuromodulatory, antioxidative, cognition enhancing, nephroprotective, antifibrotic, anti-inflammatory, and anticancer chemotherapeutic activities. This compound also inhibits PDE10A2 and acts as an antagonist at adenosine 2A and 2B receptors. In vitro, tetramethylpyrazine promotes neural progenitor cell migration and increases PI3K, PKC, and ERK signaling. Tetramethylpyrazine also induces neuroblastoma differentiation by targeting Topoisomerase Iiβ (topoIIβ). In animal models of chronic alcoholic encephalopathy, Tetramethylpyrazine improves learning and memory. Additionally, this compound inhibits arsenic-induced production of ROS and prevents apoptosis and mitochondrial dysfunction in kidney cells. Tetramethylpyrazine also ameliorates oxidative injury induced by methotrexate. In vitro, this compound inhibits proliferation of hepatic stellate cells. In animal models of hepatocellular carcinoma, tetramethylpyrazine inhibits tumor development and growth and induces cell cycle arrest and apoptosis.

References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/18832333

Cas No.

1124-11-4

Purity

≥98%

Formula

C8H12N2

Formula Wt.

136.20

IUPAC Name

Tetramethylpyrazine

Synonym

Tetramethylpyrazine; Ligustrazine


product targets : Ack1 inhibitors

Yan YX, Zhao JX, Han S, et al. Tetramethylpyrazine induces SH-SY5Y cell differentiation toward the neuronal phenotype through activation of the PI3K/Akt/Sp1/TopoIIβ pathway. Eur J Cell Biol. 2015 Dec;94(12):626-41. PMID: 26518113.

Kong X, Zhong M, Su X, et al. Tetramethylpyrazine Promotes Migration of Neural Precursor Cells via Activating the Phosphatidylinositol 3-Kinase Pathway. Mol Neurobiol. 2015 Nov 28. [Epub ahead of print]. PMID: 26614511.

Zhang B, Lu C, Bai M, et al. Tetramethylpyrazine identified by network pharmacology approaches ameliorates methotrexate-induced oxidative organ injury. J Ethnopharmacol. 2015 Oct 1. [Epub ahead of print]. PMID: 26435225.

Li H, Yang X, Shi W, et al. Protective Effects of Tetramethylpyrazine on Cerebrovascular Regulations in Rats with Chronic Alcoholic Encephalopathy. Biomed Environ Sci. 2015 Sep;28(9):691-5. PMID: 26464259.

Gong X, Ivanov VN, Hei TK. 2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-κB, AP-1 and MAPK pathways in human proximal tubular cells. Arch Toxicol. 2015 Sep 24. [Epub ahead of print]. PMID: 26404762.

Hu J, Cao G, Wu X, et al. Tetramethylpyrazine Inhibits Activation of Hepatic Stellate Cells through Hedgehog Signaling Pathways In Vitro. Biomed Res Int. 2015;2015:603067. PMID: 26380286.

Zhao S, Zhang Y, Chen Q, et al. A modified “double-hit” induced acute lung injury model in rats and protective effects of tetramethylpyrazine on the injury via Rho/ROCK pathway. Int J Clin Exp Pathol. 2015 May 1;8(5):4581-7. PMID: 26191148.

Cao J, Miao Q, Zhang J, et al. INHIBITORY EFFECT OF TETRAMETHYLPYRAZINE ON HEPATOCELLULAR CARCINOMA: POSSIBLE ROLE OF APOPTOSIS AND CELL CYCLE ARREST. J Biol Regul Homeost Agents. 2015 Apr-Jun;29(2):297-306. PMID: 26122217.

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