10-Gingerol
10-Gingerol is originally found in species of Zingiber; it exhibits antiemetic, anticancer, antioxidative, anti-inflammatory, and antibiotic activities. 10-Gingerol increases radical scavenging of superoxide and hydroxyl radicals, inhibits oxidative burst activity, and decreases expression of NO and PGE2 in vitro. 10-Gingerol also inhibits 5-HT3 receptors. Additionally, 10-gingerol inhibits proliferation in breast adenocarcinoma cells. This compound also displays antibacterial efficacy against gram negative bacteria such as Porphyromonas and Prevotella.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18831696
| Cas No. |
23513-15-7 |
|---|---|
| Purity |
≥99% |
| Formula |
C21H34O4 |
| Formula Wt. |
350.49 |
| IUPAC Name |
(5S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)tetradecan-3-one |
| Melting Point |
30-30°C |
| Appearance |
Off white-tan powder |
product targets : Enolase inhibitors
Almada da Silva J, Becceneri AB, Sanches Mutti H, et al. Purification and differential biological effects of ginger-derived substances on normal and tumor cell lines. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Aug 15;903:157-62. PMID: 22858304.
Dugasani S, Pichika MR, Nadarajah VD, et al. Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol. J Ethnopharmacol. 2010 Feb 3;127(2):515-20. PMID: 19833188.
Park M, Bae J, Lee DS. Antibacterial activity of [10]-gingerol and [12]-gingerol isolated from ginger rhizome against periodontal bacteria. Phytother Res. 2008 Nov;22(11):1446-9. PMID: 18814211.
Abdel-Aziz H, Windeck T, Ploch M, et al. Mode of action of gingerols and shogaols on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum. Eur J Pharmacol. 2006 Jan 13;530(1-2):136-43. PMID: 16364290.
