A prediction of this speculation is that a ubiquitinated kind of dMfn exists, at the very least transiently, in wt flies, and that the abundance of this ubiquitinated type of dMfn will be significantly decreased in PINK1 and parkin mutants
Since PINK1B9 males are sterile and the PINK1 gene resides on the X chromosome, we are only capable to produce male PINK1B9 mutants and consequently applied wt males as the…